Search results for "Best evidence"
showing 4 items of 4 documents
Oxidative stress and frailty : a systematic review and synthesis of the best evidence
2017
Objective Oxidative stress (OS) is associated with accelerated aging. Previous studies have suggested a possible relationship between OS and frailty but this association remains unclear. We conducted a systematic review to investigate potential interactions between OS and frailty. Methods A systematic literature search of original reports providing data on ‘OS and antioxidant’ parameters and frailty was carried out across major electronic databases from inception until May 2016. Cross-sectional/case control and longitudinal studies reporting data on the association between frailty and anti-oxidants-OS biomarkers were considered for inclusion. Results were summarized with a synthesis based o…
Medidas de Tromboprofilaxis en Artroplastia Total de Rodilla. Práctica habitual en la Comunidad Valenciana y revisión bibliográfica.
2020
espanolAntecedentes: El tromboembolismo es una complicacion de la cirugia de artroplastia total de rodilla. Para su prevencion disponemos de multiples medidas fisicas y farmacologicas.Objetivo:Conocer quemedidas de prevencion tromboembolica son las empleadas por los cirujanos ortopedicos en cirugia protesica de rodilla primaria en diferentes centros hospitalarios de nuestra region.Metodo: Estudio transversal descriptivo observacional basado en encuesta dirigida a especialistas COT de 9 hospitales publicos de la Comunidad Valenciana y busqueda bibliografica.Resultados: Se obtuvieron 64 encuestas. Todos los cirujanos eligen HBPM durante un mes como medida de tromboprofilaxis, descartando anti…
The mutual relationship between heart failure and atrial fibrillation
2020
Atrial fibrillation (AF) and heart failure (HF) are evolving epidemies, together responsible for substantial human suffering and health-care expenditure. The simultaneous co-hexistence of the two conditions is associated with mortality rates higher than those observed in individuals with only one or none of them. Patients with concomitant HF and AF suffer from even worse symptoms and poorer prognosis, yet evidence-based evaluation and management of this group of patients is lacking. In this review, we evaluate the common mechanisms for the development of AF in HF patients and vice versa, focusing on the evidence for potential treatment strategies. Recent data have suggested that these patie…
Clinical trials in children.
2006
Abstract Randomized controlled clinical trials are felt by the medical community to provide the best evidence. Participation in trials involves the possibility of obtaining benefits but also of suffering some risks. Those risks are often considered unacceptable for children but if clinical trials are not conducted in children, clinicians are forced to extrapolate study data from adults. In 1968 H. Shirkey termed children "therapeutic orphans" because of the lack of adequately tested and labeled drugs available in appropriate formulations. Research involving children entails specific difficulties as the need to study children of different ages, the small number of children affected by certai…